According to the United States Census Bureau, the town has a total area of 38.8 square miles (100.4 km²), of which, 38.1 square miles (98.7 km²) of it is land and 0.6 square miles (1.7 km²) of it (1.68%) is water.

Durham is bordered by Pownal, Auburn, Freeport, New Gloucester, Brunswick, and Lisbon Falls. Some debate whether or not Durham shares a border with Topsham and Lewiston or not. Technically, if Durham shares a border with Lisbon Falls, it shares a border with Topsham and Lewiston. A straight line from Durham across the Androscoggin River can reach Topsham and Lewiston, as it can reach Lisbon Falls.

Durham is in the Maine's 2nd US Congressional District, Maine Senate District 15, and Maine House of Representatives District 105.

Durham Area Code is 207

• Durham Elementary School is a public school operated by the Durham School Department. The school provides for the education of students in grades K through 8.
• Education of a majority of the students in grades 9 through 12 is provided by Brunswick High School.
• High school education is also offered by Lisbon High School, Edward Little High School, and Freeport High School.

• Town of Durham, ME - 630 Hallowell Road Durham, Maine 04222
  Telephone: 207 353-2561 Fax: 207 353-5367
• Durham Elementary School - 48 Gorham Road, Scarborough, ME 04074
  Phone: 207-353-9333 Fax: 207-353-2731
• Durham Fire and Rescue - Office Location: 615 Hallowell Road Durham, ME 04222
  Telephone: 207 353-2473